The PAM Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PAM. This antibody recognizes Human, Mouse, and Rat antigen. The PAM Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Subunit Structure: Monomer. Interacts with RASSF9 (By similarity).
Similarity: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family